(1R,2S)-1-Amino-2-indanol - CAS 136030-00-7

Name: (1R,2S)-1-Amino-2-indanol
Brand: BOC Sciences
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(1R,2S)-(+)-cis-1-Amino-2-indanol (CAS# 136030-00-7) is a useful research chemical.

Catalog Number

136030-00-7

CAS

136030-00-7

IUPAC Name

(1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Synonyms

(1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol; (1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Molecular Weight

149.19

Molecular Formula

C9H11NO

Product Information

Canonical SMILES

C1C(C(C2=CC=CC=C21)N)O

InChI

InChI=1S/C9H11NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,8-9,11H,5,10H2/t8-,9+/m0/s1

InChI Key

LOPKSXMQWBYUOI-DTWKUNHWSA-N

Purity

99 %

MDL

MFCD00216656

Physical State

Solid

Appearance

Powder or crystals

Storage

Keep in dark place. Inert atmosphere. Room temperature.

Boiling Point

290 °C at 760 mmHg

Melting Point

116 °C

Density

1.212 g/cm³

Optical Activity

43° (c=1 in methanol)

WGK Germany

Safety Information

Signal Word

Danger

Precautionary Statement

P261, P272, P273, P280, P302+P352, P305+P351+P338, P310, P321, P333+P313, P363, and P501

Hazard Statements

H315 - H319 - H335

Reference Reading

1. Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols.

Beatriz Lantaño, Esteban A Ugliarolo, Rodolfo H Campos, Albertina G Moglioni, Lucía V Cavallaro, Dolores Gagey, Graciela Y Moltrasio. Bioorg Med Chem. 2012 Oct 1; 20(19): 5986-91. DOI: 10.1016/j.bmc.2012.07.028. PMID: 22944333.

New chiral purinyl and 8-azapurinyl carbanucleoside derivatives based on indanol were synthesized from commercial available (1S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated against herpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darby bovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds, showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside, derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.

The molarity calculator equation

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