Technical Information

30 Aug 2022

Chromatography is based on converting the mixture of enantiomers into diastereomers, and then using their differences in chemical or physical properties for separation. Chromatography mainly includes gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE) and capillary electrochromatography (CEC).

30 Aug 2022

The chirality of drug molecules is closely related to the pharmacological activity, toxicity and pharmacokinetic properties of drugs. Compared with the racemates of chiral drugs, single optically active chiral drugs have clear therapeutic targets, higher efficacy and safety, and lower adverse reactions.

30 Aug 2022

A certain chirality is involved in most biological processes. In order to understand the function of chiral molecules in biological systems, it is very important to determine the absolute configuration of chiral molecules. Currently, there are four main methods for determining the absolute configuration of chiral molecules: (1) chemical correlation method, (2) nuclear magnetic resonance, (3) X-ray diffraction, (4) spectroscopy.

30 Aug 2022

In liquid chromatography, the mobile phase composition, chiral stationary phase type and instrument operating conditions all contribute to the resolution of chiral compounds. Among them, the selectivity of the chiral stationary phase takes precedence over the composition of the mobile phase, which takes precedence over the operating conditions of the instrument.

25 Oct 2022

Chiral chromatographic columns can be divided into liquid chiral chromatographic columns and gas chiral chromatographic columns. Liquid chiral chromatography columns can be further divided into natural products, including natural product modifications, and polymers. Among them, the chiral column of polysaccharide and its derivatives is a general chiral column, and it is also the most widely used chiral column at present.

25 Oct 2022

Commonly used mobile phase-dependent elution modes can be divided into normal phase liquid chromatography (NPLC), polar and polar ion mode mobile phases, and reversed phase liquid chromatography (RPLC). The types and characteristics of compounds available for each mobile phase are different and limited by the combination of column and stationary phase matrix.

11 May 2023

Evans' Chiral Auxiliaries are a family of chiral compounds developed by Professor David A. Evans at Harvard University. These compounds are used in asymmetric synthesis to control the stereochemistry of reactions. Evans' Chiral Auxiliaries are widely used in the pharmaceutical industry for the synthesis of chiral drugs and have been instrumental in the development of many new drugs.