Chirality plays an important role in the fields of asymmetric synthesis, biology and medicine. Therefore, it is of great significance to analyze chiral compounds quickly, sensitively, and selectively. BOC Sciences can perform chiral analysis following regulatory standards. We offer chiral column screening, chiral analysis method development and optimization services. Our chiral analysis experts can characterize the enantiomers of chiral compounds for your research needs.
Chirality is one of the basic characteristics of nature. An object is chiral if it cannot overlap with its mirror image. In such a case, there are two possible forms of the same object, which are called enantiomers. Enantiomers have the same chemical and physical properties in an achiral environment, which means that the enantiomers have the same melting point, solubility, retention time, infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) spectra. However, they behave differently in a chiral environment, which is especially important in biological systems (such as our bodies). The living system is a chiral environment. For example, among the 20 most basic natural amino acids, except for the simplest structure of glycine, the other 19 natural amino acids are all single isomers with chiral centers, which are connected by these chiral units. When a pair of enantiomers bind to a protein, the situation is different. Therefore, the enantiomers often behave differently when interacting with other chiral compounds.
Figure 1 The interaction of chiral molecules and proteins
Taking advantage of their differences, the separation and analysis of enantiomers can finally be achieved.
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