(+)-Diethyl L-tartrate - CAS 87-91-2

(+)-Diethyl L-tartrate is a chiral resolution reagent to separate racemic compounds into different mirror isomers and is an important tool for the production of optically active drugs.

Product Information

Canonical SMILES
CCOC(=O)[C@H](O)[C@@H](O)C(=O)OCC
Purity
≥98%, ≥95%e.e.
MDL
MFCD00009143
Physical State
Liquid
Appearance
Clear colourless liquid
Storage
Sealed in dry. Room temperature.
Boiling Point
162 ℃ / 19 mmHg
Melting Point
17 ℃
Flash Point
93 °C(199.4 °F)
Density
1.2 g/mL at 25 ℃
Optical Activity
+8.5°(neat)
Solubility
Insoluble in water.
pK Values
pKa: 11.61
Refractive Index
1.45
TSCA
Yes
WGK Germany
3

Safety Information

Signal Word
Warning
Precautionary Statement
P210 - P264b - P280 - P302+P352 - P305+P351+P338 - P332+P313 - P362 - P370+P378q - P501c - X
Hazard Statements
H315 - H319 - H335

Reference Reading

1. Separation of corticosteroids by microemulsion ekc with diethyl l-tartrate as the oil phase.
Guan-Ren Wang, Chuen-Ying Liu, Tse-Hsien Chen, Kuan-Pin Huang, Chi-Hung Wu. Electrophoresis. 2007 Oct; 28(20): 3691-6. DOI: 10.1002/elps.200700358. PMID: 17893939.
A novel microemulsion based on a mixture of diethyl L-tartrate (DET) and SDS was developed for the microemulsion EKC (MEEKC) determination of structurally related steroids. The system consisted of 0.5% w/w DET, 1.7% w/w SDS, 1.2% w/w 1-butanol, 89.6% w/w phosphate buffer (40 mM, pH 7.0), and 7% w/w ACN. With an applied voltage of +10 kV, a baseline separation of aldosterone (A), cortisone acetate (CA), dexamethasone (D), hydrocortisone (H), hydrocortisone acetate (HA), prednisolone (P), prednisolone acetate (PA), prednisone (Ps), triamcinolone (T), and triamcinolone acetonide (TA) could be achieved. Under the optimized conditions, the reproducibility of the retention time (n = 4) for most of the compounds was less than +/-0.8% with the exception of A, Ps, and T. The average number of theoretical plates was 18 800 plates/m. The results were compared with those achieved by the modified micellar EKC (MEKC). MEEKC showed obvious advantages over MEKC for the separation of highly hydrophobic substances. To further evaluate the system, we tested the MEEKC method by analyzing corticosteroids in a spiked urine sample.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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