Pidotimod Impurity (L-Thiaproline) - CAS 34592-47-7

Name: Pidotimod Impurity (L-Thiaproline)
Brand: BOC Sciences
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Pidotimod Impurity (L-Thiaproline) is a sulfur-containing pyrrolidine carboxylic acid derivative relevant for advanced analytical, synthetic, and metabolic research. As a structural analog of proline, it exhibits unique conformational preferences, often influencing peptide backbone flexibility in model systems. Its inherent sulfur atom introduces distinct redox and catalytic properties, making it valuable for probing enzyme selectivity and reactivity. L-Thiaproline is frequently employed in studies of amino acid metabolism, peptide engineering, and the synthesis of modified peptides with novel bioactive profiles.

Catalog Number

BCC-00317

CAS

34592-47-7

IUPAC Name

(4R)-1,3-thiazolidine-4-carboxylic acid

Synonyms

Timonacic; L-Thiazolidine-4-carboxylic acid; T4C.

Molecular Weight

133.17

Molecular Formula

C4H7NO2S

Product Information

Canonical SMILES

C1C(NCS1)C(=O)O

InChI

InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1

InChI Key

DZLNHFMRPBPULJ-VKHMYHEASA-N

Purity

≥ 98.5% (assay)

MDL

MFCD00005212

Physical State

Solid

Appearance

White powder

Storage

Store at RT

Boiling Point

350.3°C at 760 mmHg

Melting Point

>195°C (dec.)

Density

1.38 g/cm3

Optical Activity

-141°(c=1.3 in water)

Solubility

Soluble in DMSO, Water

Hazard Class

6.1

TSCA

WGK Germany

Packing Groups

III

Safety Information

Signal Word

Danger

Precautionary Statement

P261 - P280 - P305+P351+P338 - P311

Hazard Statements

H302H312 - H315 - H319 - H331 - H335

Reference Reading

1.Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications.

Bakry RS1, Razak OA, el Walily AF, Belal SF. J Pharm Biomed Anal. 1998 May;17(1):95-101.

A simple spectrophotometric method for the determination of timonacic is presented. The procedure is based on the chelate formation with palladium(II) chloride in buffered medium. The optimum conditions for the complex formation were ascertained and the method was developed for the determination of timonacic in the concentration range of 28-48 micrograms ml-1. The emperical formula of the formed complex was determined, by applying different spectrophotometric methods, at optimum pH of 4.8 and an ionic strength of mu = 0.5. The stoichiometric ratio was found to be 2:1 (timonacic/palladium) as calculated by the mole ratio, continuous variations and Asmus methods. The continuous variations and Nash methods were applied for the determination of the conditional stability constant of the formed yellow-water soluble complex and was found to be 3.27 x 10(7). The proposed methods was found to be suitable for the determination of timonacic in bulk and in its pharmaceutical tablets.

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