N-Boc-trans-4-hydroxy-L-prolinol - CAS 61478-26-0

N-Boc-trans-4-hydroxy-L-prolinol is a protected amino alcohol derived from the natural amino acid L-proline, featuring a trans-4-hydroxy modification and a tert-butoxycarbonyl (Boc) protecting group. This compound is structurally significant for peptide synthesis, as the Boc protection enables selective deprotection and functionalization during solid-phase elongation. Its hydroxy group confers enhanced reactivity, facilitating cyclization and heterocycle construction in advanced organic synthesis. Frequently utilized in the development of complex peptide analogs and as a versatile intermediate in medicinal chemistry research, N-Boc-trans-4-hydroxy-L-prolinol supports studies in protein engineering and molecular scaffold design.

Catalog Number

BCC-01297

CAS

61478-26-0

IUPAC Name

tert-butyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Synonyms

Boc-Hyp-ol; Boc-Pro(4-Hydroxy)-ol; N-(t-Butoxycarbonyl)-trans-4-hydroxy-L-prolinol; (2S,4R)-1-(t-Butoxycarbonyl)-4-hydroxy-2-hydroxymethylpyrrolidine; (2S,4R)-Tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate; Tert-butyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Molecular Weight

217.27

Molecular Formula

C10H19NO4